| Pair Name | Curcumin, Temozolomide | ||
| Phytochemical Name | Curcumin (PubChem CID: 969516 ) | ||
| Anticancer drug Name | Temozolomide (PubChem CID: 5394 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Drug Name | Temozolomide |
| Adverse Reactions | Nausea, vomiting. This was inferred cold nature anticancer drug. |
| Recommendations | Hot: Amomum tsao-ko; Curcuma longa; Acorus calamus; Alpinia officinarum; Curcuma kwangsiensis |
| Reference | ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899. ref_link |
| Pair Name | Curcumin, Temozolomide | |||
| Disease Info | [ICD-11: 2A00] | Glioblastoma multiforme | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Down-regulation | Expression | BDNF | hsa627 | |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Down-regulation | Expression | HSP90AA1 | hsa3320 | |
| Down-regulation | Expression | HSPA4 | hsa3308 | |
| Down-regulation | Expression | HSPB1 | hsa3315 | |
| Up-regulation | Expression | TNF | hsa7124 | |
| Up-regulation | Expression | TP53 | hsa7157 | |
| In Vitro Model | U-87MG ATCC | Glioblastoma | Homo sapiens (Human) | CVCL_0022 |
| Result | We showed for the first time that exosomes released from drug-treated U87 cells could be a new therapeutic approach in glioblastoma, and could reduce the side effects produced by drugs alone. This concept needs to be further examined in animal models before clinical trials could be considered. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Exosomes released from U87 glioma cells treated with curcumin and/or temozolomide produce apoptosis in naive U87 cells. Pathol Res Pract. 2023 May;245:154427. doi: 10.1016/j.prp.2023.154427. | Click |
